Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4266 | 4266-30612 | Germany | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, V75M, L210W | T215S, K219N | Y181C | M16T, V35T, E36D, T39R, K43E, V60I, K101KR, D121H, K122E, I135T, A158AT, S162CY, D177E, I178M, V189VI, Q197K, T200A, I202V, Q207E, R211K, V245T, D250E, A272P, K277R, T286A, I293IV, E297K, A304E, P345Q, F346Y, R356RK, R358K, E370G, T377H, S379C, K390R |
| >4266-30612| codons 1-399 PISPIETVPVKLKPGTDGPKVKQWPLTEEKIKALTDICRELEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKVMDFRELNKRTQDFWEVQLGIPHPAGLRKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPTIFQYSMTKILEPFRKQNPEMVI CQYMDDLYIGSDLEIGKHRAKVEELREHLWKWGFSTPDNKHQKEPPFLWMGYELHPDKWT VQPITLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTKEAE LELEENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEQYKNLKTGKYAKMKGA HTNDVKQLTGAVQKIAHECIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82VA, L90LM | L10FI, L24LI, L33IMV, Q58QE | I13IV, K14KR, L19I, K20KT, P39PA, R41RK, K55KR, R57RK, I62V, L63E, I64V, A71AV, T74AE, L89M |
| >4266-30612| codons 1-99 PQITLWQRPIVTVRIGGQITEALIDTGADDTVVEEMNLAGKWKPKLIGGIGGFVRVKEYD QVEVEICGHKVIGEVLVGPTPANIIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |