<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4266 4266-30612 Germany 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82VA, L90LM L10FI, L24LI, L33IMV, Q58QE I13IV, K14KR, L19I, K20KT, P39PA, R41RK, K55KR, R57RK, I62V, L63E, I64V, A71AV, T74AE, L89M  
>4266-30612| codons 1-99
PQITLWQRPIVTVRIGGQITEALIDTGADDTVVEEMNLAGKWKPKLIGGIGGFVRVKEYD
QVEVEICGHKVIGEVLVGPTPANIIGRNMMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W V75M, T215S, K219N Y181C   M16T, V35T, E36D, T39R, K43E, V60I, K101KR, D121H, K122E, I135T, A158AT, S162CY, D177E, I178M, V189VI, Q197K, T200A, I202V, Q207E, R211K, V245T, D250E, A272P, K277R, T286A, I293IV, E297K, A304E, P345Q, F346Y, R356RK, R358K, E370G, T377H, S379C, K390R  
>4266-30612| codons 1-399
PISPIETVPVKLKPGTDGPKVKQWPLTEEKIKALTDICRELEEEGKISKIGPENPYNTPI
FAIKKKNSTKWRKVMDFRELNKRTQDFWEVQLGIPHPAGLRKKKSVTVLDVGDAYFSVPL
HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPTIFQYSMTKILEPFRKQNPEMVI
CQYMDDLYIGSDLEIGKHRAKVEELREHLWKWGFSTPDNKHQKEPPFLWMGYELHPDKWT
VQPITLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTKEAE
LELEENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEQYKNLKTGKYAKMKGA
HTNDVKQLTGAVQKIAHECIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006