Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4264 | 4264-30616 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82T, L90M | L10F, L89V | T12K, I13V, Q18H, K20I, E35ED, M36I, N37DE, R41E, K55R, D60K, I62V, L63P, C67F, H69R, A71V |
| >4264-30616| codons 1-99 PQITLWQRPFVKVKIGGHLIEALLDTGADDTVLEDIELPGEWKPKIIGGVGGFVRVRQYK QVPIEIFGRKVIGTVLVGPTPTNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74I, V75T, M184V, T215F | K219Q | K20R, I94IL, K101Q, V118I, K122E, I135L, Q174R, D177E, G196E, T200TA, E203D, F214L, K223Q, L228H, A272P, K277R, A288S, E297K, G333E, M357I, A360T, K366KR, T386TI, K390R, E399D | N137H |
| >4264-30616| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKITDFRELNKRTQDFWEVQLGLPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNHETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIVI YQYVDDLYVGSDLEIEQHRAKIDELRQHLLRWGLFTPDQKHQQEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARIRGT HTNDVRQLTEAVQKIATESIVIWGKIPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |