Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4263 | 4263-30605 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, I84V, L90M | L33F, F53L | L10I, V11VL, I13IV, D60E, L63P, A71V, I72T, V77VI, I93L |
| >4263-30605| codons 1-99 PQITLWQRPILTVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGLVKVRQYE QIPIEICGHKVTGTVLIGPTPFNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K32KR, V35I, K43E, V118I, K122E, A158S, G196E, T200A, E203K, Q207E, H208Y, R211K, L228H, Q278H, T286A, I293V, E297A, D324E, G335GS, G359S, K366KR, A371V, A376S, T377M |
| >4263-30605| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALIEICTELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRAKIKELREYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARMRSA HTNDVRQLTEVVQKISMESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |