Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4262 | 4262-30530 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A, L90M | L33F, F53L | L10I, G16A, L19I, E34Q, N37D, L63P, H69Y, A71T, I72IT |
| >4262-30530| codons 1-99 PQITLWQRPIVTIKIAGQIKEALLDTGADDTIFQEMDLPGRWKPKIVGGIGGLVKVRQYD QIPIEICGYKTTGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219E | K103KN | V35T, T69N, K122E, S162SN, T200TI, R211S, R284K, T286A, E297R, I326IV, I329L, A360T, K395R, E399D |
| >4262-30530| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELRQHLLSWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLVAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |