Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4261 | 4261-30530 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, I84V, L90M | L10F, V11VI, L33I, Q58E, L89V | I13V, Q18QH, K20M, M36I, I62V, L63P, A71T, P79A, T91S, Q92K |
| >4261-30530| codons 1-99 PQITLWQRPFITVKIGGHLMEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFIKVREYD QVPIEICGHKTIGTVVVGATPVNVIGRNVMSKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69A_XG, V75M, L210W, T215HY | D67DE | Y181C, G190A | S68G, K101Q, V106VI, K122E, I135T, I142V, S163SAGT, L228K, K277R, Q278QE, L283LI, E297K, Q334L, M357I, A360T, T386I |
| >4261-30530| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKEGAKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLQKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSTMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFKWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLIRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARIRGT HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |