Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4259 | 4259-30530 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | L33F | L10I, V11L, N37S, L63P, A71L, I72IV, V77I, I93L |
| >4259-30530| codons 1-99 PQITLWQRPILTIKIGGQLKEALLDTGADDTIFEEMSLPGRWKPKIVGGIGGFMKVRQYD QIPIEICGHKLVGTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, T215Y | D67G, K219E | Y181I | V179D | K20R, S68G, K122E, I135T, R172K, Q174K, D177E, E203D, R211G, E224D, A272P, K277R, T286TA, A288S, I293V, Q334CSY, M357T, G359GS, T369V, T386I, K390R |
| >4259-30530| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKGGTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKKNPEIDI IQYVDDLYVGSDLEIGQHRTKIDELRQHLLGWGFYTPDEKHQKDPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGYGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLVEAVQKIATESIVIWGKIPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |