<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4256 4256-30715 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, V75M, T215F K219Q K103H, Y181C, G190A A98G, V108I S3SC, T7P, E28K, K32E, V60I, T69N, K82R, D121H, K122E, I135T, I142V, Q174R, D177E, V189VI, G196E, T200A, E203D, Q207E, H221Y, L228H, A272P, K277R, I293IV, V317A, S322T, Q334D, K350R, T369A, A376S, K390R  
>4256-30715| codons 1-399
PICPIEPVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSNRWRKLMDFRELNRRTQDFWEVQLGIPHPGGLKKHKSVTILDVGDAYFSVPL
HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIVI
CQYMDDLYIASDLEIEQHRAKIDELREHLLRWGFFTPDQKYQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGAYYDPTKDLIAEIQKQGDGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLAEAVQKISTESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82F, L90M L23I, F53FL, Q58E L10I, K20R, E35D, M36I, K55R, R57RK, I62V, L63P, I64IL, I66V, H69HR, A71T, I72V, V77I, I93L, C95F  
>4256-30715| codons 1-99
PQITLWQRPIVTIKIGGQLREAILDTGADDTVLEDINLPGRWKPKIIGGIGGLVRVKEYD
QVPLEVCGRKTVGTVLIGPTPFNIIGRNLMTQLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006