Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4256 | 4256-30715 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, L90M | L23I, F53FL, Q58E | L10I, K20R, E35D, M36I, K55R, R57RK, I62V, L63P, I64IL, I66V, H69HR, A71T, I72V, V77I, I93L, C95F |
| >4256-30715| codons 1-99 PQITLWQRPIVTIKIGGQLREAILDTGADDTVLEDINLPGRWKPKIIGGIGGLVRVKEYD QVPLEVCGRKTVGTVLIGPTPFNIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, T215F | K219Q | K103H, Y181C, G190A | A98G, V108I | S3SC, T7P, E28K, K32E, V60I, T69N, K82R, D121H, K122E, I135T, I142V, Q174R, D177E, V189VI, G196E, T200A, E203D, Q207E, H221Y, L228H, A272P, K277R, I293IV, V317A, S322T, Q334D, K350R, T369A, A376S, K390R |
| >4256-30715| codons 1-399 PICPIEPVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLMDFRELNRRTQDFWEVQLGIPHPGGLKKHKSVTILDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIVI CQYMDDLYIASDLEIEQHRAKIDELREHLLRWGFFTPDQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGAYYDPTKDLIAEIQKQGDGQWTYQIYQEPFKNLRTGKYARMRGA HTNDVKQLAEAVQKISTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |