Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2099 | CA7748 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 4 |
| 2 | 3TC+D4T | 30 |
| 3 | 3TC+D4T+IDV | 52 |
| 4 | ADV+NVP+NFV+SQV | 47 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215HY | K219KN | K103N, Y181YC | A98S, A158AS, E169ED, D177E, Q197E, R211K |
| >CA7748| codons 1-255 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILDPFRKQNPEIVI CQYMDDLYVGSDLEIGEHRTKIEELRQHLWKWGFHTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVN |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10FI, L24LI | I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63C, A71V, L89M, I93L |
| >CA7749| codons 1-99 PQITLWQRPFVTIKVGGQLREALIDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVKQYD QVCIEICGHKVIGTVLVGPTPANIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |