Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4253 | 4253-30602 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215F | K219R, N348I | K103N | V108I | K102Q, K122E, I135V, I142T, S162C, E169D, I178L, H208Y, R211K, H221Y, V245M, A272P, L283I, R284K, I293V, S322T, I329L, G335D, A355T, M357T, K366R, E399G |
| >4253-30602| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGTRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFFTPDRKYQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIKGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAELQKQGQDQWTYQIYQEPFKILKTGKYTRTRGA HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWGA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82A, L90M | G73S | I15V, E35D, M36I, N37D, I62V, L63P, A71V, I93L |
| >4253-30602| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTILEDIDLPGRWKPKIVGGIGGFIKVRQYD QVPIEICGHKVISTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |