Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4250 | 4250-30526 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K43N, E44D, K101Q, V118I, K122E, I142V, Q174R, G196E, I202IV, Q207D, R211K, L228HQ, A272P, K277KR, L283I, T286P, I293V, E297K, A304E, E312A, I329L, G333D, Q334H, A360T, T386TI, K395R, E399ED |
| >4250-30526| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYVDDLYVGSDLEIEQHRTKVEELRDHLWKWGFYTPDKKHQKEPPFQWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGPKALTEVVPLTKEAE LELEENREILKAPVHGVYYDPSKDLIAELQKQDHGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQRETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L89V | L10I, I13V, Q18QH, L33M, R41K, K43R, Q61H, L63P, A71V, I72M, I93L |
| >4250-30526| codons 1-99 PQITLWQRPIVTVKIGGHLKEALLDTGADDTVMEEMNLPGKWRPKMIGGIGGFVKVRQYD HIPIEICGHKVMGTVLVGPTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |