<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4250 4250-30526 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M L89V L10I, I13V, Q18QH, L33M, R41K, K43R, Q61H, L63P, A71V, I72M, I93L  
>4250-30526| codons 1-99
PQITLWQRPIVTVKIGGHLKEALLDTGADDTVMEEMNLPGKWRPKMIGGIGGFVKVRQYD
HIPIEICGHKVMGTVLVGPTPVNVIGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y       K43N, E44D, K101Q, V118I, K122E, I142V, Q174R, G196E, I202IV, Q207D, R211K, L228HQ, A272P, K277KR, L283I, T286P, I293V, E297K, A304E, E312A, I329L, G333D, Q334H, A360T, T386TI, K395R, E399ED  
>4250-30526| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI
YQYVDDLYVGSDLEIEQHRTKVEELRDHLWKWGFYTPDKKHQKEPPFQWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGPKALTEVVPLTKEAE
LELEENREILKAPVHGVYYDPSKDLIAELQKQDHGQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQRETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006