<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4249 4249-30721 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215Y K219Q, N348I K101E   K32KQ, V35I, V60VI, A98S, I135R, D177E, I202V, E203K, Q207D, L228H, V245K, L283I, I293IV, T296TS, E297A, P321PS, D324DE, A327AV, I329IV, I341F, R356K, G359S, K366R, T377R, T386I  
>4249-30721| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALIEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRTKVKELRDHLLRWGFYTPDQKHQKEPPFHWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVPLSAEAE
LELAENREILKEPVHGVYYDSSKELIVEVQKQGQGQWTYQFYQEPFKILKTGKYAKMRSA
HTNDVRQLTEAVQKIARESIVIWGKIPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A K43T, T74P L10V, I13V, I15V, L19V, K20M, E35D, M36I, N37NK, R41K, I62V, L63Q, I64V, L89M  
>4249-30721| codons 1-99
PQITLWQRPVVTVKVGGQVMEALLDTGADDTVLEDIKLPGKWTPKLIGGIGGFVKVRQYD
QVQVEICGHKAIGPVLVGPTPANIIGRNMLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006