Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4249 | 4249-30721 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | K43T, T74P | L10V, I13V, I15V, L19V, K20M, E35D, M36I, N37NK, R41K, I62V, L63Q, I64V, L89M |
| >4249-30721| codons 1-99 PQITLWQRPVVTVKVGGQVMEALLDTGADDTVLEDIKLPGKWTPKLIGGIGGFVKVRQYD QVQVEICGHKAIGPVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215Y | K219Q, N348I | K101E | K32KQ, V35I, V60VI, A98S, I135R, D177E, I202V, E203K, Q207D, L228H, V245K, L283I, I293IV, T296TS, E297A, P321PS, D324DE, A327AV, I329IV, I341F, R356K, G359S, K366R, T377R, T386I |
| >4249-30721| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALIEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKVKELRDHLLRWGFYTPDQKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVPLSAEAE LELAENREILKEPVHGVYYDSSKELIVEVQKQGQGQWTYQFYQEPFKILKTGKYAKMRSA HTNDVRQLTEAVQKIARESIVIWGKIPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |