Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4248 | 4248-30617 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, L210W, T215Y | K219Q, N348I | K103S, G190AS | K238T | V35L, T39AE, E44D, K64KR, I94L, K122E, I135T, V189VI, H208Y, R211K, L228H, Q242H, V245E, A272P, I293V, E297K, R356K, M357R, G359S, S379G, K390R |
| >4248-30617| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICEELEKDGKISKIGPENPYNTPV FAIRKKNSTRWRKIVDFRELNKRTQDFWEVQLGLPHPAGLKKSKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYISSDLEIGQHRTKIEELRQYLWKWGFYTPDQKHQKEPPFHWMGYELHPDTWT VHPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYAKRRSA HTNDVKQLTEAVQKIATEGIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, L90M | L23I, L33F, F53L, G73C | I13V, E35D, M36L, L63P, A71AT, I72IT, V82I, I93L |
| >4248-30617| codons 1-99 PQITLWQRPLVTVKIGGQLKEAILDTGADDTIFEDLNLPGRWKPKIVGGIGGLLKVRQYD QIPIEICGHKTTCTVLVGPTPINIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |