<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4248 4248-30617 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54L, L90M L23I, L33F, F53L, G73C I13V, E35D, M36L, L63P, A71AT, I72IT, V82I, I93L  
>4248-30617| codons 1-99
PQITLWQRPLVTVKIGGQLKEAILDTGADDTIFEDLNLPGRWKPKIVGGIGGLLKVRQYD
QIPIEICGHKTTCTVLVGPTPINIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, L210W, T215Y K219Q, N348I K103S, G190AS K238T V35L, T39AE, E44D, K64KR, I94L, K122E, I135T, V189VI, H208Y, R211K, L228H, Q242H, V245E, A272P, I293V, E297K, R356K, M357R, G359S, S379G, K390R  
>4248-30617| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICEELEKDGKISKIGPENPYNTPV
FAIRKKNSTRWRKIVDFRELNKRTQDFWEVQLGLPHPAGLKKSKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYISSDLEIGQHRTKIEELRQYLWKWGFYTPDQKHQKEPPFHWMGYELHPDTWT
VHPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYAKRRSA
HTNDVKQLTEAVQKIATEGIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006