Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4247 | 4247-30519 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I50V, I54A, V82A | L33F, Q58E | L10I, E34Q, P39Q, F53FY, D60E, Q61E, I62V, L63T, A71V, I72T, V77I, I93L |
| >4247-30519| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQEMNLQGRWKPKIIVGVGGYAKVREYE EVTIEICGHKVTGTVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, M184V, T215F | K219Q | K101EQ, Y181C, G190A | K122E, S162D, V179I, R211K, D218E, L228H, V245T, S251SC, K281R, T286A, E297K, I329L, G333E, Q334H, G359GS, K366R, T369V, A376T, T377M, T386I |
| >4247-30519| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIII CQYVDDLYVASDLEIGQHRTKIEELRQHLLKWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPITLPEKDCWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQEHGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVRQLVEAVQKITMESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |