<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4247 4247-30519 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, I50V, I54A, V82A L33F, Q58E L10I, E34Q, P39Q, F53FY, D60E, Q61E, I62V, L63T, A71V, I72T, V77I, I93L  
>4247-30519| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQEMNLQGRWKPKIIVGVGGYAKVREYE
EVTIEICGHKVTGTVLIGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74I, M184V, T215F K219Q K101EQ, Y181C, G190A   K122E, S162D, V179I, R211K, D218E, L228H, V245T, S251SC, K281R, T286A, E297K, I329L, G333E, Q334H, G359GS, K366R, T369V, A376T, T377M, T386I  
>4247-30519| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIII
CQYVDDLYVASDLEIGQHRTKIEELRQHLLKWGFFTPEQKHQKEPPFHWMGYELHPDKWT
VQPITLPEKDCWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQEHGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVRQLVEAVQKITMESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006