<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4246 4246-40630 Germany 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 51

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82ST, I84IV L10F E35D, M36V, N37E, R41K, R57K, L63P, A71V, I93L  
>4246-40630| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEDVELPGKWKPKMIGGIGGFVKVKQYD
QIPIEICGHKVIGTVLVGPTPTNVIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, T215F D67G, K219E K103N   E6D, K20KR, V60I, S68G, D123E, D177N, T200I, V245E, A272P, T286A, I293V, S322A, I326V, G333E, Q334H, M357T, R358K, A371V, E396D  
>4246-40630| codons 1-399
PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI
YQYMDDLYVGSDLEIGQHRIKIEELRQHLLRWGFFTPDEKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPAKDLVAEIQKQEHGQWTYQIYQEPFKNLKTGKYARTKGA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKDTWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006