Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4246 | 4246-40630 | Germany | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 51 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82ST, I84IV | L10F | E35D, M36V, N37E, R41K, R57K, L63P, A71V, I93L |
| >4246-40630| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEDVELPGKWKPKMIGGIGGFVKVKQYD QIPIEICGHKVIGTVLVGPTPTNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, T215F | D67G, K219E | K103N | E6D, K20KR, V60I, S68G, D123E, D177N, T200I, V245E, A272P, T286A, I293V, S322A, I326V, G333E, Q334H, M357T, R358K, A371V, E396D |
| >4246-40630| codons 1-399 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYMDDLYVGSDLEIGQHRIKIEELRQHLLRWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPAKDLVAEIQKQEHGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKDTWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |