<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4246 4246-30708 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A L10F, L24I I3IV, E35D, M36I, N37E, R57K, L63P, A71V, I93L  
>4246-30708| codons 1-99
PQVTLWQRPFVTIKIGGQLKEALIDTGADDTVLEDIELPGRWKPKIIGGIGGFVKVKQYD
QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L74LI, M184V, T215F D67G, K219E K103N   E6D, V60VI, S68G, D123E, V189VI, T200I, R211RK, V245E, K249KR, A272P, T286A, I293V, S322A, I326V, G333E, Q334H, M357T, R358K, A371V, E396D  
>4246-30708| codons 1-399
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKGGTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYIGSDLEIGQHRIKIEELRQHLLKWGFFTPDEKHQKEPPFLWMGYELHPDKWT
VQPIELPERDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPAKDLVAEIQKQEHGQWTYQIYQEPFKNLKTGKYARTKGA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKDTWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006