Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
48-4246 | 4246-30708 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | PI|NRTI|NNRTI | NA |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
M46I, I54V, V82A | L10F, L24I | I3IV, E35D, M36I, N37E, R57K, L63P, A71V, I93L |
>4246-30708| codons 1-99 PQVTLWQRPFVTIKIGGQLKEALIDTGADDTVLEDIELPGRWKPKIIGGIGGFVKVKQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, K70R, L74LI, M184V, T215F | D67G, K219E | K103N | E6D, V60VI, S68G, D123E, V189VI, T200I, R211RK, V245E, K249KR, A272P, T286A, I293V, S322A, I326V, G333E, Q334H, M357T, R358K, A371V, E396D, A400T |
>4246-30708| codons 1-400 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKGGTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYIGSDLEIGQHRIKIEELRQHLLKWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPIELPERDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPAKDLVAEIQKQEHGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKDTWET |
References
Author | Title | Citation |
Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |