Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4241 | 4241-40707 | Germany | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 59 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54A | N88D, L89V | L10I, I13V, Q18H, K20M, L33V, N37D, K55R, L63P, I66V, A71I, I72V, V77VI, Q92K |
| >4241-40707| codons 1-99 PQITLWQRPIVTVKIGGHLMEALLDTGADDTVVEEMDLPGRWKPKIVGGIGGFARVRQYD QIPIEVCGHKIVGTVLIGPTPVNIIGRDVLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70KR, Q151M, M184V | A62V, V75I, F77L, F116Y, K219Q | Y181C, G190GA | A98G | E28R, V35M, I50IV, K101A, V118I, K122KE, T165TI, D177DE, E203K, Q207E, F214L, K277R, E291D, I293V, M357V, T369V, A376T, V381I, T386A, K390R |
| >4241-40707| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTREKIKALMEICTEMEKEGKISKVGPENPYNTPVF VIKKKNSDRWRKLIDLRELNKRTQDFWEVQLGIPHPGGLAKKKSVTVLDVGDAYYSIPLD EDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMIKILEPFRKQNPEIVIC QYVDDLYVASDLEIGQHRTKIKELREHLLRWGLTTPDQKHQKEPPFLWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTDVVPLTEEAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGAH TNDVKQLVEAVQKITTESIIIWGKAPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |