<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4241 4241-31126 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 26

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, Q151M, M184V A62V, V75I, F77L, F116Y, K219Q Y181C A98G V10VI, E28R, V35M, I50V, K101A, V118I, K122KE, D177E, G196GDE, E203K, Q207E, F214L, K277R, E291D, I293V, M357V, T369V, A376T, V381VI, T386A, K390R  
>4241-31126| codons 1-399
PISPIETVPIKLKPGMDGPKVKQWPLTREKIKALMEICTEMEKEGKISKVGPENPYNTPV
FVIKKKNSDRWRKLIDLRELNKRTQDFWEVQLGIPHPGGLAKKKSVTVLDVGDAYYSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPEIVI
CQYVDDLYVGSDLEIEQHRTKIKELREHLLRWGLTTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTDVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGA
HTNDVKQLVEAVQKITTESIIIWGKAPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54A N88D, L89V L10I, I13V, Q18H, K20M, N37D, K55R, L63P, A71I, I72V, V77I, Q92K  
>4241-31126| codons 1-99
PQITLWQRPIVTVKIGGHLMEALLDTGADDTVLEEMDLPGRWKPKIVGGIGGFARVRQYD
QIPIEICGHKIVGTVLIGPTPVNIIGRDVLTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006