Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4241 | 4241-31126 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 26 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M, M184V | A62V, V75I, F77L, F116Y, K219Q | Y181C | A98G | V10VI, E28R, V35M, I50V, K101A, V118I, K122KE, D177E, G196GDE, E203K, Q207E, F214L, K277R, E291D, I293V, M357V, T369V, A376T, V381VI, T386A, K390R |
| >4241-31126| codons 1-399 PISPIETVPIKLKPGMDGPKVKQWPLTREKIKALMEICTEMEKEGKISKVGPENPYNTPV FVIKKKNSDRWRKLIDLRELNKRTQDFWEVQLGIPHPGGLAKKKSVTVLDVGDAYYSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVGSDLEIEQHRTKIKELREHLLRWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTDVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGA HTNDVKQLVEAVQKITTESIIIWGKAPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54A | N88D, L89V | L10I, I13V, Q18H, K20M, N37D, K55R, L63P, A71I, I72V, V77I, Q92K |
| >4241-31126| codons 1-99 PQITLWQRPIVTVKIGGHLMEALLDTGADDTVLEEMDLPGRWKPKIVGGIGGFARVRQYD QIPIEICGHKIVGTVLIGPTPVNIIGRDVLTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |