Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4241 | 4241-30523 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M, M184V | A62AV, V75VI, F77L, F116Y, K219Q | Y181C, G190A | A98G | E28KR, V35M, I50V, K101A, V118VI, K122E, D177E, E203K, Q207E, F214L, K277R, E291ED, I293V, M357MV, T369AV, A376T, V381I, T386A, K390R |
| >4241-30523| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTREKIKALMEICTEMEKEGKISKVGPENPYNTPV FVIKKKNSDRWRKLIDLRELNKRTQDFWEVQLGIPHPGGLAKKKSVTVLDVGDAYYSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVASDLEIGQHRTKIKELREHLLRWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTDVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGA HTNDVKQLVEAVQKITTESIIIWGKAPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, L76V | L89V | L10I, I13V, Q18H, K20M, M36MI, N37D, K55R, Q61QH, L63P, A71T, I72V |
| >4241-30523| codons 1-99 PQITLWQRPIVTVKIGGHLMEALLDTGADDTVLEEIDLPGRWKPKIIGGVGGFIRVRQYD HIPIEICGHKTVGTVVVGPTPVNIIGRNVLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |