Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4238 | 4238-30513 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R, L74I, V75M, M184I, L210W, T215F | D67G, K219W | K103N, Y181C, G190A | K20R, V35M, K64H, V118I, K122E, D123DN, I135T, S162A, T165I, P170PL, G196R, T200A, F214L, D218E, L228H, V245K, S251V, T286A, I293V, R356K, A371V, I375V, K390R, K395R, E399D |
| >4238-30513| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIHKKGSDRWRKIMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMIKILELFRKQNPDIVI CQYIDDLYVASDLEIRQHRAKIEELRQHLWRWGLFTPEWKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDVWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQRETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, L90M | L33F, K43T, F53L, T74P | L10V, I13V, L19I, K20R, E35D, M36I, N37D, K55R, I62V, L63P, A71V, I93L |
| >4238-30513| codons 1-99 PQITLWQRPVVTVKIGGQIREALLDTGADDTVFEDIDLPGRWTPKLIGGIGGLLRVRQYD QVPIEICGHKVIGPVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |