<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4238 4238-30513 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54L, V82A, L90M L33F, K43T, F53L, T74P L10V, I13V, L19I, K20R, E35D, M36I, N37D, K55R, I62V, L63P, A71V, I93L  
>4238-30513| codons 1-99
PQITLWQRPVVTVKIGGQIREALLDTGADDTVFEDIDLPGRWTPKLIGGIGGLLRVRQYD
QVPIEICGHKVIGPVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T69D, K70R, L74I, M184I, L210W, T215F D67G, V75M, K219W K103N, Y181C, G190A   K20R, V35M, K64H, V118I, K122E, D123DN, I135T, S162A, T165I, P170PL, G196R, T200A, F214L, D218E, L228H, V245K, S251V, T286A, I293V, R356K, A371V, I375V, K390R, K395R, E399D  
>4238-30513| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV
FAIHKKGSDRWRKIMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMIKILELFRKQNPDIVI
CQYIDDLYVASDLEIRQHRAKIEELRQHLWRWGLFTPEWKHQKEPPFHWMGYELHPDKWT
VQPIKLPEKDVWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQRETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006