<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4237 4237-30508 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, M184V, T215F K219Q, N348I G190S   E6K, K49R, V118I, K122E, S162D, Q174K, N175Y, V179I, T200A, E203D, Q207E, R211A, F214L, L228H, A272P, E297Q, K311R, Q334E, R356K, M357S, K366R, A376T, K390R  
>4237-30508| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKKYPDIII
YQYVDDLYVSSDLEIGQHRAKIDELREHLLAWGLFTPDQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTQEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKILKTGKYAKSRGA
HTNDVRQLTEAVQKITTESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M G73T L10I, V11L, I15V, K20I, E35D, M36I, I62V, L63P, A71V, I85V  
>4237-30508| codons 1-99
PQITLWQRPILTIKVGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVITTVLVGPTPVNVVGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006