Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4237 | 4237-30508 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | G73T | L10I, V11L, I15V, K20I, E35D, M36I, I62V, L63P, A71V, I85V |
| >4237-30508| codons 1-99 PQITLWQRPILTIKVGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVITTVLVGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q, N348I | G190S | E6K, K49R, V118I, K122E, S162D, Q174K, N175Y, V179I, T200A, E203D, Q207E, R211A, F214L, L228H, A272P, E297Q, K311R, Q334E, R356K, M357S, K366R, A376T, K390R |
| >4237-30508| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKKYPDIII YQYVDDLYVSSDLEIGQHRAKIDELREHLLAWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTQEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKILKTGKYAKSRGA HTNDVRQLTEAVQKITTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |