<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4234 4234-30429 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y   K101P, Y181C V108I K20R, V35L, T39A, K43AE, E44D, R83K, V118I, D123E, I135V, K166Q, D177E, V179L, G196E, T200A, E203D, H208Y, R211K, H221Y, E224D, A272P, K277R, T286TP, A288S, E297R, S322T, I329V, G333E, K350R, R356RK, G359S, V365I, T369A, A371V, A376T, T386A, K390R  
>4234-30429| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEEDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLPKKKSVTILDVGDAYFSIPL
DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTQILEPFRKQNPEILI
CQYMDDLYVGSDLEIEQHRAKIDELRQYLWKWGFYTPDKKYQKDPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGPKSLTEVIPLTREAE
LELAENREILKEPVHGVYYDPTKDLIAEVQKQEQGQWTYQIYQEPFKNLRTGKYAKMRSA
HTNDIKQLAEVVQKITTESIVIWGKAPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54M, V82S L33F L10I, I13IV, E34EQ, N37S, D60E, I62V, L63P, A71I, I72L, V77I, I93L  
>4234-30429| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFQEMSLPGRWKPKMIVGIGGFMKVRQYE
QVPIEICGHKILGTVLIGPTPSNIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006