Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4234 | 4234-30429 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K101P, Y181C | V108I | K20R, V35L, T39A, K43AE, E44D, R83K, V118I, D123E, I135V, K166Q, D177E, V179L, G196E, T200A, E203D, H208Y, R211K, H221Y, E224D, A272P, K277R, T286TP, A288S, E297R, S322T, I329V, G333E, K350R, R356RK, G359S, V365I, T369A, A371V, A376T, T386A, K390R |
| >4234-30429| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLPKKKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTQILEPFRKQNPEILI CQYMDDLYVGSDLEIEQHRAKIDELRQYLWKWGFYTPDKKYQKDPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGPKSLTEVIPLTREAE LELAENREILKEPVHGVYYDPTKDLIAEVQKQEQGQWTYQIYQEPFKNLRTGKYAKMRSA HTNDIKQLAEVVQKITTESIVIWGKAPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54M, V82S | L33F | L10I, I13IV, E34EQ, N37S, D60E, I62V, L63P, A71I, I72L, V77I, I93L |
| >4234-30429| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFQEMSLPGRWKPKMIVGIGGFMKVRQYE QVPIEICGHKILGTVLIGPTPSNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |