Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4233 | 4233-30513 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | Y188L | T39A, E44D, S68G, A98S, D123E, S162SN, I178IM, V189VI, E203D, Q207E, H208Y, R211K, Q242QL, A272P, K281R, T286P, I293V, E297R, I329L, G333E, M357MT, A360T, S379SC, K390KR, E399D |
| >4233-30513| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDMVI YQYVDDLLIGSDLEIGQHRTKIDELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VLPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGPKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYARTRGT HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, T74TP | K20R, E34Q, E35D, M36I, N37D, R57K, I62IV, L63P, I66V, V82VI, Q92K, I93L, C95F |
| >4233-30513| codons 1-99 PQITLWQRPFVTIKIGGQLREALLDTGADDTVFQDIDLPGRWKPKIIGGIGGFVKVKQYD QVPIEVCGHKAIGPVLVGPTPINVIGRNLMTKLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |