Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4232 | 4232-30428 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | Y181C, G190A | A98G, K101H | V35L, T39A, K43E, E44A, V118I, D121H, K122E, D177G, G196E, E203K, L205F, Q207E, H208Y, R211K, K223E, L228H, A272P, K277R, V292I, E297Q, G333E, Q334H, G359S, T386I |
| >4232-30428| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLHKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVI CQYVDDLYVASDLEIEQHRTKIKEFREYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIIPLTQEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, Q58QE | L10I, I15V, K20R, E35D, M36I, N37E, R57RK, I62V, L63P, L89M, Q92K |
| >4232-30428| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDIELPGRWKPKLIGGIGGFVKVKEYD QVPIEICGHKAIGTVLVGPTPANIIGRNMLTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |