<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4232 4232-30428 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I, Q58QE L10I, I15V, K20R, E35D, M36I, N37E, R57RK, I62V, L63P, L89M, Q92K  
>4232-30428| codons 1-99
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDIELPGRWKPKLIGGIGGFVKVKEYD
QVPIEICGHKAIGTVLVGPTPANIIGRNMLTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N Y181C, G190A A98G, K101H V35L, T39A, K43E, E44A, V118I, D121H, K122E, D177G, G196E, E203K, L205F, Q207E, H208Y, R211K, K223E, L228H, A272P, K277R, V292I, E297Q, G333E, Q334H, G359S, T386I  
>4232-30428| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLHKKKSVTVLDVGDAYFSIPL
HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVI
CQYVDDLYVASDLEIEQHRTKIKEFREYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIIPLTQEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006