Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4231 | 4231-30618 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82S | L24I, L33I, F53FL, Q58E | L10I, I13V, L19V, K20M, E35D, M36I, N37S, R41K, K55R, I62V, L63P, I64V, A71V, T74S, I93L |
| >4231-30618| codons 1-99 PQITLWQRPIVTVKIGGQVMEALIDTGADDTVIEDISLPGKWKPKIIGGIGGLVRVREYD QVPVEICGHKVIGSVLVGPTPSNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K101E, Y181C, G190A | A98G | T39A, K43Q, E44D, S68G, V118I, D123E, I135T, E203K, Q207DE, R211K, R284RK, I293V, E297K, I309IL, Q334E, Y339W, R356K, G359S, A360AV, V365I, K390R |
| >4231-30618| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIKELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVVPLTKEAE LELAENRELLKEPVHGVYYDPSKDLIAEIQKQGEGQWTWQIYQEPFKNLKTGKYAKMRSV HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |