Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4229 | 4229-30507 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46LV, I84V | L33LF | L10LI, I62MV, L63P, H69N, V82I |
| >4229-30507| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKVIGGIGGFIKVRQYD QVPIEICGNKAIGTVLVGPTPINVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70KR, M184V | E6D, D123E, I135L, K173E, I178M, A272P, K277R, P294T, E297K, I329V, T338S, M357T, A371V, A376T, T386A, K390R |
| >4229-30507| codons 1-399 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDMVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVITLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWSYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKITTESIVIWGKAPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |