<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4228 4228-30430 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Y115F, Q151M, M184I A62V, V75I, F77L, F116Y K103N, Y181C, G190A   I31T, V35I, T58N, S68SR, R83K, V118I, K122E, D123N, T165I, G196R, R211K, F214L, R358K, T369A, A376T, K390R  
>4228-30430| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKTKALIEICTEMEKEGKISKIGPENPYNNPV
FVIKRKDRTKWRKLIDLRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFYSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMIKILEPFRKQNPDIVI
CQYIDDLYVASDLEIRQHRTKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA
HTNDVKQLAEAVQKITTESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, I84V, L90M K43T L10I, V11L, I13V, G16A, N37D, F53W, L63P, I64V, A71V, T91S  
>4228-30430| codons 1-99
PQITLWQRPILTVKIAGQLKEALLDTGADDTVLEEMDLPGRWTPKIIGGIGGWVKVRQYD
QIPVEICGHKVIGTVLVGPTPTNVIGRNLMSQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006