Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4228 | 4228-30430 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M, M184I | A62V, V75I, F77L, F116Y | K103N, Y181C, G190A | I31T, V35I, T58N, S68SR, R83K, V118I, K122E, D123N, T165I, G196R, R211K, F214L, R358K, T369A, A376T, K390R |
| >4228-30430| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKTKALIEICTEMEKEGKISKIGPENPYNNPV FVIKRKDRTKWRKLIDLRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFYSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMIKILEPFRKQNPDIVI CQYIDDLYVASDLEIRQHRTKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLAEAVQKITTESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V, L90M | K43T | L10I, V11L, I13V, G16A, N37D, F53W, L63P, I64V, A71V, T91S |
| >4228-30430| codons 1-99 PQITLWQRPILTVKIAGQLKEALLDTGADDTVLEEMDLPGRWTPKIIGGIGGWVKVRQYD QIPVEICGHKVIGTVLVGPTPTNVIGRNLMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |