Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4223 | 4223-30522 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54T, V82A | L24LI | L10I, G16A, K20R, E35D, M36I, N37E, R57RK, I64V |
| >4223-30522| codons 1-99 PQITLWQRPIVTIKIAGQLREALIDTGADDTVLEDIELPGRWKPKIIVGIGGFTKVKQYD QILVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| P4ST, I142V, P243PS, V245T, E248D, T286A, E297K, V317A, I329L, Q334H, A360AV, A400AT |
| >4223-30522| codons 1-400 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQSITLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAELQKQGHGQWTYQIYQEPFKNLKTGKYARMRGV HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |