Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4222 | 4222-30506 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, G73C | T4TP, E35D, M36I, N37E, I62V, L63P, I66V, I72K, I93L, C95F |
| >4222-30506| codons 1-99 PQIPLWQRPFVTIKIGGQLKEALLDTGADDTVFEDIELPGRWKPKIIGGIGGFVKVRQYD QVPIEVCGHKAKCTVLVGPTPVNVIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, V75M, M184V, L210W, T215Y | D67DG, F77L, K219R | K103N | A98G, V108I, F227L | V35T, T39I, E44D, V60I, V111VIM, V118I, K122E, D123DN, I135T, G196E, T200A, E203K, H208Y, R211K, K223E, L228R, V245M, A272P, K277R, T286A, E297KR, D324E, I329L, M357T, E370D, S379C |
| >4222-30506| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICIELEKDGKISKIGPENPYNTPI FAIKKKGSDKWRKLMDLRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDMGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRAKIKELRQYLWKWGFYTPDRKHQEEPPLRWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTDAVQKIATECIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |