Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4221 | 4221-30429 | Germany | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215Y | K219E | K103N, Y188L | V35T, T39TA, S68SG, I94L, S105T, K122E, I135V, S162A, K173T, D177G, T200A, I202V, Q207E, P243Q, V245Q, K281R, T286A, E291D, I293V, P294T, P313T, S322T, I326IV, G335D, R356K, M357K, G359S, A371V, I375V, A376S, K390R, K395KR |
| >4221-30429| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPV FAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGLPHPAGLKKNKTVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTQNPGIVI YQYVDDLLVGSDLEIGQHRAKVEELREHLLRWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQQIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDVVTLTEEAE LELAENREILKETVHGVYYDPTKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVKQLTEVVQKVSTESIVIWGKTPKFRLPIQRETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | L10F, L33I, G73S | I13V, K14R, K20I, E21ED, A22V, M36I, N37D, R41K, L63LP, H69K, K70R, A71V, L89T |
| >4221-30429| codons 1-99 PQITLWQRPFVTVRIGGQLIDVLLDTGADDTVIEEIDLPGKWKPKIIGGIGGFIKVRQYD QIPIEICGKRVISTVLVGPTPVNVIGRNTLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |