<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4221 4221-30429 Germany 2003 HIV1 CRF02_AG Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, T215Y K219E K103N, Y188L   V35T, T39TA, S68SG, I94L, S105T, K122E, I135V, S162A, K173T, D177G, T200A, I202V, Q207E, P243Q, V245Q, K281R, T286A, E291D, I293V, P294T, P313T, S322T, I326IV, G335D, R356K, M357K, G359S, A371V, I375V, A376S, K390R, K395KR  
>4221-30429| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPV
FAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGLPHPAGLKKNKTVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTQNPGIVI
YQYVDDLLVGSDLEIGQHRAKVEELREHLLRWGFYTPDEKHQKEPPFLWMGYELHPDKWT
VQQIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDVVTLTEEAE
LELAENREILKETVHGVYYDPTKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA
HTNDVKQLTEVVQKVSTESIVIWGKTPKFRLPIQRETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V L10F, L33I, G73S I13V, K14R, K20I, E21ED, A22V, M36I, N37D, R41K, L63LP, H69K, K70R, A71V, L89T  
>4221-30429| codons 1-99
PQITLWQRPFVTVRIGGQLIDVLLDTGADDTVIEEIDLPGKWKPKIIGGIGGFIKVRQYD
QIPIEICGKRVISTVLVGPTPVNVIGRNTLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006