Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4220 | 4220-30423 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L210W, T215Y | D67H, T69G, V75A, K219D | K103N, Y181C, G190A | V108I | K20R, V35M, K43Q, E44D, S68N, L109I, K122E, D123E, I135T, R172K, R211RK, D218E, L228H, V245K, A272P, T286A, I326V, Q334N, R356K, G359S, T369V, A376S, K390R |
| >4220-30423| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV FAIKKKHNGRWRKLADFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTIIDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI CQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPEDKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLVEAVQKISTESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I50V, I54S, V82A | L10I, E34Q, F53Y, I62V, L63Q, A71V, I72V, T74S, V77I, I93L |
| >4220-30423| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLQEMNLPGRWKPKIIVGVGGYSKVRQYD QVQIEICGHKVVGSVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |