<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4220 4220-30423 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L210W, T215Y D67H, T69G, V75A, K219D K103N, Y181C, G190A V108I K20R, V35M, K43Q, E44D, S68N, L109I, K122E, D123E, I135T, R172K, R211RK, D218E, L228H, V245K, A272P, T286A, I326V, Q334N, R356K, G359S, T369V, A376S, K390R  
>4220-30423| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV
FAIKKKHNGRWRKLADFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTIIDVGDAYFSVPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
CQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPEDKHQKEPPFHWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLVEAVQKISTESIVIWGKTPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, I50V, I54S, V82A   L10I, E34Q, F53Y, I62V, L63Q, A71V, I72V, T74S, V77I, I93L  
>4220-30423| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLQEMNLPGRWKPKIIVGVGGYSKVRQYD
QVQIEICGHKVVGSVLIGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006