Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4219 | 4219-30423 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN, M46MI, I54V, V82VAIT, L90LM | L10FI, L33LF, F53FL, N88D | T12TP, I13V, I15IV, G16E, K20KT, E35EG, M36X, R41RK, K45T, I62V, L63S, I64IV, C67CY, A71AV, I72IV, V77VI, I93IL |
| >4219-30423| codons 1-99 PQITLWQRPIVPVKVEGQLTEALLDTGADNTVFEGVNLPGKWKPTIIGGIGGLVKVRQYD QVSVEIYGHKVVGTVLIGPTPTNIIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67DN, L210LW | T215TN, K219N | Y181YC, G190GA | K101KHNQ | K43KN, K122KE, A272P, K277R, A288AS, Q334E, M357MT, A360AT, K366KR, T369AV, A371AT, I375V, I393IM, A400S |
| >4219-30423| codons 2-400 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPVF AIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPLD EDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIC QYMDDLYVASDLEIGQHRTKIEELRQHLWRWGFNTPDNKHQKEPPFLWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVIPLTEEAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRGTH TNDVRQLVETVQKVATESIVIWGKTPKFKLPMQKETWES |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |