Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4217 | 4217-30915 | Germany | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L33F, K43T, N88G | L10I, I13V, K14R, K20R, E21Q, E35D, M36I, N37D, Q61N, I62V, L63Q, H69K, A71L, T74S, Q92R, I93M |
| >4217-30915| codons 1-99 PQITLWQRPIVTVRIGGQLRQALLDTGADDTVFEDIDLPGRWTPKLIGGIGGFVKVRQYD NVQIEICGKKLIGSVLVGPTPVNVIGRGLMTRMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| E6K, K11T, V35T, K102Q, K122E, D123N, I135T, I142V, S162Y, K173L, D177E, V179I, T200TA, I202V, Q207A, R211K, V245Q, K277R, T286A, E291D, I293V, P294T, K311R, E312D, I326V, M357K, G359S, K366R, T369V, A371V, I375V, A376V |
| >4217-30915| codons 1-399 PISPIKTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRLQNPEIII YQYMDDLYVGSDLEIGQHRAKVEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDVVTLTEEAE LELAENREILRDPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARKRSA HTNDVRQLVEVVQKVVTESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |