<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4217 4217-30915 Germany 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, I84V, L90M L33F, K43T, N88G L10I, I13V, K14R, K20R, E21Q, E35D, M36I, N37D, Q61N, I62V, L63Q, H69K, A71L, T74S, Q92R, I93M  
>4217-30915| codons 1-99
PQITLWQRPIVTVRIGGQLRQALLDTGADDTVFEDIDLPGRWTPKLIGGIGGFVKVRQYD
NVQIEICGKKLIGSVLVGPTPVNVIGRGLMTRMGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6K, K11T, V35T, K102Q, K122E, D123N, I135T, I142V, S162Y, K173L, D177E, V179I, T200TA, I202V, Q207A, R211K, V245Q, K277R, T286A, E291D, I293V, P294T, K311R, E312D, I326V, M357K, G359S, K366R, T369V, A371V, I375V, A376V  
>4217-30915| codons 1-399
PISPIKTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRLQNPEIII
YQYMDDLYVGSDLEIGQHRAKVEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDVVTLTEEAE
LELAENREILRDPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARKRSA
HTNDVRQLVEVVQKVVTESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006