<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4216 4216-30710 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, V11I, G73S T12TK, I15V, K20I, E35D, M36I, N37D, K55KR, R57K, I62V, L63P, A71IT, I72IR, P79PA, I93L  
>4216-30710| codons 1-99
PQITLWQRPFIKIKVGGQLIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVRVKQYD
QVPIEICGHKTRSTVLVGATPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74V, T215F K219Q L100LI, K103N   I2V, K20R, V35VL, K43E, E44A, S117A, V118I, I135T, S162A, D177DN, H208Y, L210LV, R211K, F214L, D218E, L228H, T286A, A288T, E297D, G359S, A376S, T386I, K390R  
>4216-30710| codons 1-399
PVSPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFAIPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPNIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQYLVKWGLFTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKTLTEVIPLTDEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006