Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4216 | 4216-30710 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, G73S | T12TK, I15V, K20I, E35D, M36I, N37D, K55KR, R57K, I62V, L63P, A71IT, I72IR, P79PA, I93L |
| >4216-30710| codons 1-99 PQITLWQRPFIKIKVGGQLIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVRVKQYD QVPIEICGHKTRSTVLVGATPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74V, T215F | K219Q | L100LI, K103N | I2V, K20R, V35VL, K43E, E44A, S117A, V118I, I135T, S162A, D177DN, H208Y, L210LV, R211K, F214L, D218E, L228H, T286A, A288T, E297D, G359S, A376S, T386I, K390R |
| >4216-30710| codons 1-399 PVSPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEEAGKISKIGPENPYNTPV FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFAIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPNIVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLVKWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKTLTEVIPLTDEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |