Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4214 | 4214-30507 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L23I, L33F, Q58E, G73GS, T74TP | L10I, I13V, L24F, I62V, L63P, A71V, I93L |
| >4214-30507| codons 1-99 PQITLWQRPIVTVKIGGQLKEAIFDTGADDTVFEEMNLPGRWKPKLIGGIGGFVKVREYD QVPIEICGHKVISPVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | T69N, K122E, I142V, I178M, T200A, R211A, V245T, A272P, K277R, T286A, E297K, V317VA, Q334L, M357MT, E370ED, A371V, I375V, A376T, T386M, K390R |
| >4214-30507| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVF AIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD EDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVIY QYMDDLYVGSDLEIGQHRAKIEELRQHLLAWGFYTPDKKHQKEPPFLWMGYELHPDKWTV QPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAEL ELAENREILKEPVHGAYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARTRGAH TNDVKQLTDVVQKVTTESIVIWGKMPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |