Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4213 | 4213-30429 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | K103N | K238T | K20R, V35L, T39A, V118I, K122E, I135T, I142V, K173T, Q174K, G196E, Q207H, R211K, F214L, K223KR, P294Q, V317A, G333GE, Q334L, G359S, T369A, A371V, A376ST, S379C, T386TA, K390R, E399D |
| >4213-30429| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRHHLLKWGLFTPDQKHQREPPFLWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIQLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQELGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLAEVVQKITTECIVIWGKAPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, V82A, L90M | L10F, L33F, Q58E, L89V | I13V, K20V, E35G, M36I, N37D, R57K, D60E, I62V, L63P, A71T, Q92K |
| >4213-30429| codons 1-99 PQITLWQRPFVTVKIGGQLVEALLDTGADDTVFEGIDLPGRWKPKMIGGIGGFLKVKEYE QVPIEICGHKTIGTVLVGPTPANIIGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |