Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4211 | 4211-30507 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, T215F | K219E | K101E, G190C | E28EK, V60I, D123E, G196E, Q207H, L228LR, A272P, K275KR, K277R, Q278H, E297K, V317A, S322T, Q334L, M357T, A360V, K366R, A376AGST, T386TI, K390R |
| >4211-30507| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVCSDLEIEQHRTKIEELRHHLLRWGFFTPDEKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRHLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGAYYDPTKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARTRGV HTNDVRQLTEAVQKITTESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | L10F, L33F | I13V, L63P, H69K, A71V, I93L |
| >4211-30507| codons 1-99 PQITLWQRPFVTVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGKKVIGTVVVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |