Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4210 | 4210-30429 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A, L90M | L10F, L33F, G73S, L89V | T4P, I13V, G16A, L19I, M36L, N37E, I62IV, L63P, C67CF, H69K, A71V, I72M |
| >4210-30429| codons 1-99 PQIPLWQRPFVTVKIAGQIKEALLDTGADDTVFEELELPGRWKPKLIGGIGGFVKVRQYD QVPIEIFGKKVMSTVVVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | N348I | Y188L | K43Q, V118I, K122E, V179I, T200TA, R211K, D237DN, A272P, K277KR, K281R, E297R, Q334D, I341F, T386I, K390R, E399D |
| >4210-30429| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLLVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPNKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQFYQEPFKILKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |