<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4208 4208-30423 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74V, T215Y K219Q K103N, Y181C, G190A   P4PH, K20R, S117SA, K122E, D123E, I135T, S162C, R172RK, D177E, G196E, R211T, D218E, L228H, V261VI, T286A, E297AP, V317A, I329L, E344D, F346Y, M357T, T386TI, K390R E44DY
>4208-30423| codons 1-399
PISHIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKYGKISKIGPENPYNTPV
FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFAVPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPEIVI
CQYMDDLYVASDLEIEQHRTKIEELRQHLLTWGFYTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLIGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTPEAE
LELAENREILKEPVHGAYYDPSKDLIAELQKQGQGQWTYQIYQDPYKNLKTGKYARTRGA
HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, G48GV, I50IV, I54IT, V82VA L33LF L10I, I13IV, I15IV, L19IT, K20KR, M36MI, R41K, L63AT, A71AV, I72IV, T74S, I93L  
>4208-30423| codons 1-99
PQITLWQRPIVTVKVGGQTREALLDTGADDTVFEEINLPGKWKPKIIVGVGGFTKVRQYD
QITIEICGHKVVGSVLVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006