Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4208 | 4208-30423 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48GV, I50IV, I54IT, V82VA | L33LF | L10I, I13IV, I15IV, L19IT, K20KR, M36MI, R41K, L63AT, A71AV, I72IV, T74S, I93L |
| >4208-30423| codons 1-99 PQITLWQRPIVTVKVGGQTREALLDTGADDTVFEEINLPGKWKPKIIVGVGGFTKVRQYD QITIEICGHKVVGSVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, T215Y | K219Q | K103N, Y181C, G190A | P4PH, K20R, S117SA, K122E, D123E, I135T, S162C, R172RK, D177E, G196E, R211T, D218E, L228H, V261VI, T286A, E297AP, V317A, I329L, E344D, F346Y, M357T, T386TI, K390R | E44DY |
| >4208-30423| codons 1-399 PISHIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKYGKISKIGPENPYNTPV FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFAVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPEIVI CQYMDDLYVASDLEIEQHRTKIEELRQHLLTWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLIGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTPEAE LELAENREILKEPVHGAYYDPSKDLIAELQKQGQGQWTYQIYQDPYKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |