Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4207 | 4207-30530 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210W, T215Y | K219E | L100I, K103N | A98G | P4PS, K20R, E44ED, V60I, V118I, K122E, D123N, S162D, H208Y, R211K, D218E, L228H, T286A, E297KRT, S322T, I329L, R356RK, T386I, E399ED |
| >4207-30530| codons 1-399 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTTEAE LELAENREILKEPVHGVYYDPTKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84IV | L10FI, L24I, L33F, K43T | L19V, K20R, E35D, M36I, L63P, A71V, T91S |
| >4207-30530| codons 1-99 PQITLWQRPIVTIKIGGQVREALIDTGADDTVFEDINLPGRWTPKMIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANVIGRNLLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |