Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4205 | 4205-40304 | Germany | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 46 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I84V, L90M | L10LF, F53L, G73ST | K20I, L33LV, L63P, H69Q, A71V, N83S, I85V, T91A |
| >4205-40304| codons 1-99 PQITLWQRPFVTIKIGGQLIEALLDTGADDTVVEEMNLPGRWKPKIVGGIGGLIKVRQYD QIPIEICGQKVITTVLVGPTPVSVVGRNLMAQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70KR, L74LV, L210W, T215Y | K219Q | K101E, Y181C, G190A | A98G | E6EK, K20R, V35M, E44D, V60I, V118I, K122E, D123N, S163SC, E169D, E203K, H208Y, R211D, L228H, A272P, K277R, I293V, E312EK, K366KR, T369TA, K390R |
| >4205-40304| codons 1-399 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPI FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSCMTKILDPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIKELRQYLWDWGFYTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKKPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVRQLAEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |