<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4205 4205-40304 Germany 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 46

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I84V, L90M L10LF, F53L, G73ST K20I, L33LV, L63P, H69Q, A71V, N83S, I85V, T91A  
>4205-40304| codons 1-99
PQITLWQRPFVTIKIGGQLIEALLDTGADDTVVEEMNLPGRWKPKIVGGIGGLIKVRQYD
QIPIEICGQKVITTVLVGPTPVSVVGRNLMAQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70KR, L74LV, L210W, T215Y K219Q K101E, Y181C, G190A A98G E6EK, K20R, V35M, E44D, V60I, V118I, K122E, D123N, S163SC, E169D, E203K, H208Y, R211D, L228H, A272P, K277R, I293V, E312EK, K366KR, T369TA, K390R  
>4205-40304| codons 1-399
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPI
FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSCMTKILDPFRKQNPDIVI
CQYMDDLYVASDLEIGQHRTKIKELRQYLWDWGFYTPDQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKKPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVRQLAEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006