<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4205 4205-30414 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I84V, L90M L10F, F53L, G73S K20I, L63P, H69Q, A71V, N83S, I85V, T91A  
>4205-30414| codons 1-99
PQITLWQRPFVTIKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIVGGIGGLIKVRQYD
QIPIEICGQKVISTVLVGPTPVSVVGRNLMAQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74LV, M184V, L210W, T215Y K219Q K101E, Y181C, G190A A98G K20R, V35M, E44D, V60I, V118I, K122E, D123N, E169D, E203K, H208Y, R211D, L228H, A272P, K277R, I293V, E312EK, T369TA, K390R  
>4205-30414| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPI
FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI
CQYVDDLYVASDLEIGQHRTKIKELRQYLWDWGFYTPDQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKKPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLAEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006